Neuroprotective Effects of Lipoxin A4 in Central Nervous System Pathologies. (9th September 2014)

• Record Type: Journal Article
• Authors: Martini, Alessandra Cadete; Forner, Stefânia; Bento, Allisson Freire; Rae, Giles Alexander
• Other Names: de Paula Rogerio Alexandre Academic Editor.
• Is Part Of: BioMed research international. Volume 2014(2014)
• Publication Date: 2014-09-09
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2014/316204
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Many diseases of the central nervous system are characterized and sometimes worsened by an intense inflammatory response in the affected tissue. It is now accepted that resolution of inflammation is an active process mediated by a group of mediators that can act in synchrony to switch the phenotype of cells, from a proinflammatory one to another that favors the return to homeostasis. This new genus of proresolving mediators includes resolvins, protectins, maresins, and lipoxins, the first to be discovered. In this short review we provide an overview of current knowledge into the cellular and molecular interactions of lipoxins in diseases of the central nervous system in which they appear to facilitate the resolution of inflammation, thus exerting a neuroprotective action.