Pharmacokinetics of Ganoderic Acids A and F after Oral Administration of Ling Zhi Preparation in Healthy Male Volunteers. (22nd April 2012)

• Record Type: Journal Article
• Authors: Teekachunhatean, Supanimit; Sadja, Sasinun; Ampasavate, Chadarat; Chiranthanut, Natthakarn; Rojanasthien, Noppamas; Sangdee, Chaichan
• Other Names: Kimura Yoshiyuki Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2012(2012)
• Publication Date: 2012-04-22
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2012/780892
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : The objectives of this paper were to evaluate the pharmacokinetics of ganoderic acids A and F after a single oral dose of the water extract of MG2-strain Ling Zhi (MG2FB-WE) and to assess the influence of food on the pharmacokinetics in 12 healthy male volunteers. This study was a single-dose, open-label, randomized, two-phase crossover study with at least 2 wk washout period. Each subject was randomly assigned to receive a single oral dose of 3, 000 mg of MG2FB-WE in granular formulation dissolved in 200 mL of warm water, either under a fasting condition, or immediately after a standard breakfast (fed condition). Blood samples were collected immediately before and at specific time points until 8 h after MG2FB-WE administration. Plasma ganoderic acids A and F concentrations were determined by using liquid chromatography-mass spectrometry (LC-MS) technique. In conclusion, the pharmacokinetic profile of both ganoderic acids under a fasting condition was characterized by rapid absorption from the gastrointestinal tract (T max at approximately 30 min) and a short elimination half-life (<40 min). Food significantly decreased C max and delayed T max, but did not affect the extent of ganoderic acid A absorption. However, concomitant food intake markedly impeded both rate and extent of ganoderic acid F absorption.