Outcomes of curative-intent radiotherapy in non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD). (July 2021) - Tang, Celion
Highlights: FEV1 (as a continuous variable) and COPD severity do not predict worse survival after NSCLC radiotherapy. Low FEV1 should not contraindicate curative-intent NSCLC radiotherapy. Patients with ILD had poor survival/high 90-day mortality after NSCLC radiotherapy. Risk/benefit assessment should inform NSCLC radiotherapy decisions in ILD patients. COPD/ILD patients were more breathless/needed more oxygen after NSCLC radiotherapy. Abstract: Outcomes of non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD n = 587) and interstitial lung disease (ILD n = 34) treated with curative-intent radiotherapy were retrospectively investigated. Presence of ILD but not decreased forced expiratory volume in 1-second correlated with poor overall survival. Increased breathlessness and oxygen requirements after radiotherapy were observed in severe/very severe COPD and ILD.