Castleman's disease masquerading as pancreatic neuroendocrine tumour. Issue 6 (24th June 2021)

• Record Type: Journal Article
• Authors: Gunda, Deepika; Naughton, Jack; Stevens, Sean Gregory; Perini, Marcos V
• Is Part Of: BMJ case reports. Volume 14:Issue 6(2021)
• Publication Date: 2021-06-24
• Subjects: pancreas and biliary tract -- general surgery -- gastrointestinal surgery; Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2021-242597
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : Castleman's disease (CD) is a rare lymphoproliferative disorder. This case report, to the best of our knowledge, is the first report of CD simulating a pancreatic neuroendocrine tumour . The patient was a 58-year-old woman who initially presented with bilateral iritis and underwent investigation for possible systemic rheumatological disease. CT of the chest demonstrated an incidental finding of a well-demarcated retropancreatic mass. As the mass was found to enhance on DOTATATE (tetraazacyclododecanetetraacetic acid-DPhe1-Tyr3-octreotate) positron emission tomography, a diagnosis of pancreatic neuroendocrine tumour was made. The patient underwent an open distal pancreatectomy and splenectomy. Histopathological examination revealed the unexpected diagnosis of hyaline vascular CD of a lymph node posterior to the pancreas. After 2 years of follow-up, there is no evidence of disease recurrence.