Extranodal NK/T cell lymphoma, nasal type: a rare diagnosis with common nasal presentation. Issue 6 (22nd June 2021)

• Record Type: Journal Article
• Authors: Mohd Ramli, Siti Sarah; Husain, Salina; Wong, Yin Ping
• Is Part Of: BMJ case reports. Volume 14:Issue 6(2021)
• Publication Date: 2021-06-22
• Subjects: ear -- nose and throat/otolaryngology -- haematology (incl blood transfusion) -- cancer intervention -- ear -- nose and throat; Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2020-236436
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : A 39-year-old man presented with bilateral nasal obstruction for 4 months and associated with hyposmia and foul-smelling nasal discharge. Nasal endoscopy showed irregular mucosa of the nasal cavity with easily bleeding. Nasal biopsy reported as extranodal Natural Killer/T cell lymphoma, nasal type. In-situ hybridisation for Epstein-Barr encoding region was positive. He was treated with six cycles of gemcitabine, oxaliplatin and L-asparaginase and peripheral blood stem cell transplant. After the treatment, he was asymptomatic until 9 months where he had splenic abscess and undergone splenectomy. He was asymptomatic of the disease for 2 years.