Maternal and neonatal outcomes in pregnancies conceived after preimplantation genetic testing. (5th April 2021)

• Record Type: Journal Article
• Authors: Gulersen, Moti; Peyser, Alexandra; Ferraro, Amanda; Goldman, Randi; Mullin, Christine; Li, Xueying; Krantz, David; Bornstein, Eran; Rochelson, Burton
• Is Part Of: Prenatal diagnosis. Volume 41:Number 7(2021)
• Page Start: 835
• Page End: 842
• Publication Date: 2021-04-05
• Subjects: Prenatal diagnosis -- Periodicals; Fetus -- Diseases -- Diagnosis -- Periodicals; Electronic journals; 618.32075
• DOI: 10.1002/pd.5937
• Languages: English
• ISSNs: 0197-3851

Abstract

Abstract: Objective: To determine whether preimplantation genetic testing (PGT) is associated with an increase in adverse maternal or neonatal outcomes in singleton and twin live births conceived via in vitro fertilization (IVF). Method: Retrospective cohort of live births resulting from IVF within a university health system between January 2014 and August 2019. Adverse maternal outcomes (e.g., hypertensive disorders of pregnancy, abnormal placentation, and preterm birth), and adverse neonatal outcomes were compared in singleton and twin pregnancies conceived after transfer of one or two PGT‐screened euploid embryos versus untested embryos in separate analyses. Multivariate backwards‐stepwise logistic regression was used to adjust for potential confounders. Results: Of 1160 live births, 539 (46.5%) resulted from PGT‐screened embryos, 1015 (87.5%) were singletons, and 145 (12.5%) were twins. After adjusting for potential confounders, there were no significant differences between the two groups with respect to hypertensive disorders of pregnancy, fetal growth restriction, preterm birth, and adverse neonatal outcomes in both analyses, as well as abnormal placentation for singletons. Conclusion: Our data suggest that IVF with PGT is not associated with an increased risk of adverse maternal or neonatal outcomes compared to IVF without PGT. Further research utilizing larger cohorts are needed before drawing definitive conclusions. Key Points: What's already known about this topic? Despite its widespread use, data regarding the impact of preimplantation genetic testing (PGT) on pregnancy outcomes are limited What does this study add? The use of PGT prior to embryo transfer is not associated with an increase in adverse maternal or neonatal outcomes in singleton and twin live births conceived via in vitro fertilization While such data may provide reassurance to couples when planning fertility treatments, further research utilizing larger cohorts with uniform testing protocols and outcomes are needed before drawing definitive conclusions