Progress in the Synthesis of Fused 1, 2, 3‐Triazoles. Issue 20 (24th May 2021)

• Record Type: Journal Article
• Authors: Kumar, Hariom; Dhameja, Manoj; Rizvi, Marziya; Gupta, Preeti
• Is Part Of: ChemistrySelect. Volume 6:Issue 20(2021)
• Page Start: 4889
• Page End: 4947
• Publication Date: 2021-05-24
• Subjects: Alkynes -- Azides -- Cycloaddition -- Fused 1, 2, 3-Triazoles -- Polycyclic framework.; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202100442
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Fused heterocycles display prodigious prominence in diverse field ranging from medicinal chemistry to material science and chemical biology to catalysis. Owing to biological importance, fused 1, 2, 3‐triazoles have gained much attention and hence, enormous efforts on its synthesis is given by the chemists. Diverse functionalized fused polycyclic 1, 2, 3‐triazole heterocycles have been designed using Huisgen's thermal intramolecular cycloaddition, copper catalyzed cycloaddition, bimetallic catalytic, greener and other miscellaneous approaches. Novel methodologies that use modified substrates such as ketones, enals, β‐keto esters, olefins, enones, C−H acids etc. in place of alkynes have been developed. Herein, synthetic methodologies to construct fused 1, 2, 3‐triazoles are briefly discussed. Abstract : The present review summaries an up to date literature survey on the advancements in the field of fused 1, 2, 3‐triazoles. Methodologies focused on traditional Huisgen's thermal cycloaddition to Sharpless "Click" reaction, various metal catalyzed coupling to green approaches and the reactions relied on azide‐alkyne to modified substrates are well discussed. In a nutshell, versatile fused 1, 2, 3‐triazole frameworks and macrocyclic architects are briefly mentioned.