The multifaceted role of cell cycle regulators in the coordination of growth and metabolism. (25th October 2020)

• Record Type: Journal Article
• Authors: Huber, Katharina; Mestres‐Arenas, Alberto; Fajas, Lluis; Leal‐Esteban, Lucia C.
• Is Part Of: FEBS journal. Volume 288:Number 12(2021)
• Page Start: 3813
• Page End: 3833
• Publication Date: 2020-10-25
• Subjects: cell cycle regulators -- cell growth -- endolysosomes -- metabolism -- mitochondria; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 572
• DOI: 10.1111/febs.15586
• Languages: English
• ISSNs: 1742-464X

Abstract

Abstract : Adapting to changes in nutrient availability and environmental conditions is a fundamental property of cells. This adaptation requires a multi‐directional coordination between metabolism, growth, and the cell cycle regulators (consisting of the family of cyclin‐dependent kinases (CDKs), their regulatory subunits known as cyclins, CDK inhibitors, the retinoblastoma family members, and the E2F transcription factors). Deciphering the mechanisms accountable for this coordination is crucial for understanding various patho‐physiological processes. While it is well established that metabolism and growth affect cell division, this review will focus on recent observations that demonstrate how cell cycle regulators coordinate metabolism, cell cycle progression, and growth. We will discuss how the cell cycle regulators directly regulate metabolic enzymes and pathways and summarize their involvement in the endolysosomal pathway and in the functions and dynamics of mitochondria. Abstract : This review discusses how the control of proliferation and cell division by cell cycle regulators is also involved in the metabolic adaptive responses when cells need to produce energy. We describe how cell cycle regulators are involved in the control of metabolic pathways, in cell growth and the functionality of organelles including endolysosomes and mitochondria.