Direct distinction of ibuprofen and flurbiprofen enantiomers by ion mobility mass spectrometry of their ternary complexes with metal cations and cyclodextrins in the gas phase. Issue 12 (26th May 2021)

• Record Type: Journal Article
• Authors: Gu, Liancheng; Wu, Fangling; Yang, Shutong; Xu, Fuxing; Dai, Xinhua; Jiang, You; Fang, Xiang; Yu, Shaoning; Ding, Chuan‐Fan
• Is Part Of: Journal of separation science. Volume 44:Issue 12(2021)
• Page Start: 2474
• Page End: 2482
• Publication Date: 2021-05-26
• Subjects: alkali metal ions -- cyclodextrins -- enantioselective analysis -- ion mobility mass spectrometry -- pharmaceuticals; Separation (Technology) -- Periodicals; Chromatographic analysis -- Periodicals; 543.089
• DOI: 10.1002/jssc.202100025
• Languages: English
• ISSNs: 1615-9306

Abstract

Abstract: Enantiomeric drugs are widely used and play important roles in pharmaceuticals. Ion mobility spectrometry coupled with mass spectrometry technology provides a unique method for distinguishing the enantiomeric drugs, enantiomeric identification, and quantitation in the gas phase. In this study, enantiomeric molecules of ibuprofen and flurbiprofen were clearly recognized by forming host–guest complex ions using trapped ion mobility time‐of‐flight mass spectrometry. Ternary complex ions can be produced easily by electrospray ionization of the mixed solutions of ibuprofen, cyclodextrins, and CaCl2, LiCl, or NaCl, as well as flurbiprofen, cyclodextrins, and CaCl2 . The relative contents of different chiral ibuprofens in a mixed solution were also quantitatively measured. This new method is a simple, effective, and a convenient enantioselective analysis method.