Cover Picture. Issue 2 (18th June 2021)

• Record Type: Journal Article
• Is Part Of: Animal models and experimental medicine. Volume 4:Issue 2(2021)
• Page Start: i
• Page End: i
• Publication Date: 2021-06-18
• Subjects: Laboratory animals -- Periodicals; Diseases -- Animal models -- Periodicals; Animal models in research -- Periodicals; Veterinary medicine -- Periodicals; Laboratory Animal Science; Disease Models, Animal; Animals, Laboratory; Animal Welfare; Veterinary Medicine; Animal models in research; Diseases -- Animal models; Laboratory animals; Veterinary medicine; Periodicals; Fulltext; Internet Resources; Periodicals; Periodicals; 616.0273
• DOI: 10.1002/ame2.12173
• Languages: English
• ISSNs: 2576-2095

Abstract

Abstract : This cover image is based on the Original Article Identification ACTA2 and KDR as key proteins for prognosis of PD‐1/PD‐L1 blockade therapy in melanoma by Wang, Y, Li, Z, Zhang, Z, Chen, X. https://doi.org/10.1002/ame2.12154 . In this article, 704 DEGs may be relevant to PD‐1/PD‐L1 blockade therapy were found by using dataset GSE96619. Analyzing the GO and KEGG pathways, a theoretical basis for PD‐1/PD‐L1 blockade therapy was provided. PPI network identified KDR and ACTA2 that could be potential biomarkers for predicting prognosis. The two hub genes in a B16F10 xenograft model and clinical samples were verified. This study revealed that ACTA2 and KDR could be used as responsive markers for PD‐1/PD‐L1 blockade therapy in melanoma.