Photoinduced homolytic decarboxylative acylation/cyclization of unactivated alkenes with α-keto acid under external oxidant and photocatalyst free conditions: access to quinazolinone derivatives. Issue 49 (25th May 2021)

• Record Type: Journal Article
• Authors: Sun, Bin; Shi, Rongcheng; Zhang, Kesheng; Tang, Xiaoli; Shi, Xiayue; Xu, Jiayun; Yang, Jin; Jin, Can
• Is Part Of: Chemical communications. Volume 57:Issue 49(2021)
• Page Start: 6050
• Page End: 6053
• Publication Date: 2021-05-25
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc02415a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A green and efficient strategy for the synthesis of quinazolinone derivatives via photo-induced decarboxylative cascade radical acylation/cyclization of unactivated alkenes has been developed under oxidant and photocatalyst free conditions. Abstract : A novel and green strategy for the synthesis of acylated quinazolinone derivatives via photo-induced decarboxylative cascade radical acylation/cyclization of quinazolinone bearing unactivated alkenes has been developed. The protocol provides a novel route to access acyl radicals from α-keto acids through a self-catalyzed energy transfer process. Most importantly, the reaction proceeded smoothly without any external photocatalyst, additive or oxidant, and could be easily scaled-up in flow conditions with sunlight irradiation.