An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques. Issue 33 (8th June 2021)
- Record Type:
- Journal Article
- Title:
- An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques. Issue 33 (8th June 2021)
- Main Title:
- An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques
- Authors:
- Joshi, Dhira
Milligan, Jennifer C.
Zeisner, Theresa U.
O'Reilly, Nicola
Diffley, John F. X.
Papageorgiou, George - Abstract:
- Abstract : An improved and expedient technique for the synthesis of peptidyl-fluoromethyl ketones is described. Abstract : An improved and expedient technique for the synthesis of peptidyl-fluoromethyl ketones is described. The methodology is based on prior coupling of an aspartate fluoromethyl ketone to a linker and mounting it onto resin-bound methylbenzhydrylamine hydrochloride. Subsequently, by utilising standard Fmoc peptide procedures, a number of short Z-protected peptides were synthesised and assessed as possible inhibitors of the main protease from SARS-CoV-2 (3CL pro ).
- Is Part Of:
- RSC advances. Volume 11:Issue 33(2021)
- Journal:
- RSC advances
- Issue:
- Volume 11:Issue 33(2021)
- Issue Display:
- Volume 11, Issue 33 (2021)
- Year:
- 2021
- Volume:
- 11
- Issue:
- 33
- Issue Sort Value:
- 2021-0011-0033-0000
- Page Start:
- 20457
- Page End:
- 20464
- Publication Date:
- 2021-06-08
- Subjects:
- Chemistry -- Periodicals
540.5 - Journal URLs:
- http://pubs.rsc.org/en/Journals/JournalIssues/RA ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d1ra03046a ↗
- Languages:
- English
- ISSNs:
- 2046-2069
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8036.750300
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 17323.xml