Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter. Issue 50 (27th May 2021)
- Record Type:
- Journal Article
- Title:
- Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter. Issue 50 (27th May 2021)
- Main Title:
- Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter
- Authors:
- Woods, Joshua J.
Rodriguez, Madison X.
Tsai, Chen-Wei
Tsai, Ming-Feng
Wilson, Justin J. - Abstract:
- Abstract : The MCU-inhibitory properties and mechanisms of action of Co 3+ amine complexes and Ru265 are described. Abstract : We report our investigation into the MCU-inhibitory activity of Co 3+ complexes in comparison to Ru265. These compounds reversibly inhibit the MCU with nanomolar potency. Mutagenesis studies and molecular docking simulations suggest that the complexes operate through interactions with the DIME motif of the MCU pore.
- Is Part Of:
- Chemical communications. Volume 57:Issue 50(2021)
- Journal:
- Chemical communications
- Issue:
- Volume 57:Issue 50(2021)
- Issue Display:
- Volume 57, Issue 50 (2021)
- Year:
- 2021
- Volume:
- 57
- Issue:
- 50
- Issue Sort Value:
- 2021-0057-0050-0000
- Page Start:
- 6161
- Page End:
- 6164
- Publication Date:
- 2021-05-27
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d1cc01623g ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 17336.xml