IgG Antibody Responses Are Preferential Compared With IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection. (22nd May 2021)

• Record Type: Journal Article
• Authors: Longley, Rhea J; White, Michael T; Brewster, Jessica; Liu, Zoe S J; Bourke, Caitlin; Takashima, Eizo; Harbers, Matthias; Tham, Wai-Hong; Healer, Julie; Chitnis, Chetan E; Monteiro, Wuelton; Lacerda, Marcus; Sattabongkot, Jetsumon; Tsuboi, Takafumi; Mueller, Ivo
• Is Part Of: Open forum infectious diseases. Volume 8:Number 6(2021)
• Publication Date: 2021-05-22
• Subjects: antibody -- IgG -- IgM -- malaria -- Plasmodium vivax -- serological exposure markers -- serology -- surveillance; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofab228
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax . Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and specificity of these markers, immunoglobulin M (IgM) in addition to immunoglobulin G (IgG) antibody responses were compared with a down-selected panel of 20 P. vivax proteins. IgM was tested using archival plasma samples from observational cohort studies conducted in malaria-endemic regions of Thailand and Brazil. IgM responses to these proteins generally had poorer classification performance than IgG.