Beneficial effects of olive oil and Mediterranean diet on cancer physio-pathology and incidence. (August 2021)

• Record Type: Journal Article
• Authors: Farràs, Marta; Almanza-Aguilera, Enrique; Hernáez, Álvaro; Agustí, Núria; Julve, Josep; Fitó, Montserrat; Castañer, Olga
• Is Part Of: Seminars in cancer biology. Volume 73(2021)
• Page Start: 178
• Page End: 195
• Publication Date: 2021-08
• Subjects: AkT protein kinase B -- AMPK AMP-activated proteinkinase -- BCa breast cancer -- Bcl2 B-cell lymphome-2 -- Bax B-cell lymphome-2-associated X protein -- c-Met tyrosine-protein kinase Met -- CRCa colorectal cancer -- EGFR epidermal growth factor -- ER estrogen receptor -- FA fatty acid -- HER2 human epidermal growth factor receptor 2 -- HT hydroxytyrosol -- LA linolenic acid -- MAPK mitogen-activated protein kinase -- MedD mediterranean diet -- mTOR mechanistic target of rapamycin -- MUFA monounsaturated fatty acids -- NF-κβ nuclear factor kappa beta -- OA oleic acid -- OC oleocanthal -- OL oleuropein -- OO olive oil -- OMWW olive mill wastewater -- PI3K phosphoinositol-3-kinase -- PPAR peroxisome proliferator-activated receptor -- PR progesterone receptor -- PCa prostate cancer -- PC phenolic compound -- RONS reactives pecies of oxygen and nitrogen -- STAT signal transducer and activators of transcription; Cancer -- Fatty acids -- Mediterranean diet -- Olive oil -- Phenolic compounds; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2020.11.011
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: Virgin olive oil is a characteristic component and the main source of fat of the Mediterranean diet. It is a mix of high-value health compounds, including monounsaturated fatty acids (mainly oleic acid), simple phenols (such as hydroxytyrosol and tyrosol), secoiridoids (such as oleuropein, oleocanthal), flavonoids, and terpenoids (such as squalene). Olive oil consumption has been shown to improve different aspects of human health and has been associated with a lower risk of cancer. However, the underlying cellular mechanisms involved in such effects are still poorly defined, but seem to be related to a promotion of apoptosis, modulation of epigenetic patterns, blockade of cell cycle, and angiogenesis regulation. The aim of this review is to update the current associations of cancer risk with the Mediterranean diet, olive oil consumption and its main components. In addition, the identification of key olive oil components involved in anticarcinogenic mechanisms and pathways according to experimental models is also addressed.