Advances in the toxicology research of microcystins based on Omics approaches. (September 2021)

• Record Type: Journal Article
• Authors: Ma, Ya; Liu, Haohao; Du, Xingde; Shi, Ziang; Liu, Xiaohui; Wang, Rui; Zhang, Shiyu; Tian, Zhihui; Shi, Linjia; Guo, Hongxiang; Zhang, Huizhen
• Is Part Of: Environment international. Volume 154(2021)
• Publication Date: 2021-09
• Subjects: Omics -- Proteomics -- Transcriptomics -- Metabolomics -- Microcystins -- Toxicity mechanisms; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2021.106661
• Languages: English
• ISSNs: 0160-4120

Abstract

Highlights: Toxic effects and mechanisms of microcystins have been revealed by omics methods. All 59 existing omics studies on microcystins toxicity were tabulated and discussed. The application status of omics in toxicology research of microcystins was summarized. The development direction of Omics in the toxicology study of microcystins was proposed. Abstract: Microcystins (MCs) are the most widely distributed cyanotoxins, which can be ingested by animals and human body in multiple ways, resulting in a threat to human health and the biodiversity of wildlife. Therefore, the study on toxic effects and mechanisms of MCs is one of the focuses of attention. Recently, the Omics techniques, i.e. genomics, transcriptomics, proteomics and metabolomics, have significantly contributed to the comprehensive understanding and revealing of the molecular mechanisms about the toxicity of MCs. This paper mainly reviews current literature using the Omics approaches to explore the toxicity mechanism of MCs in liver, gonad, spleen, brain, intestine and lung of multiple species. It was found that MCs can exert strong toxic effects on various metabolic activities and cell signal transduction in cell cycle, apoptosis, destruction of cell cytoskeleton and redox disorder, at protein, transcription and metabolism level. Meanwhile, it was also revealed that the alteration of non-coding RNAs (miRNA, circRNA and lncRNA, etc.) and gut microbiota plays an essential regulatory role in the toxic effects of MCs, especially in hepatotoxicity and reproductive toxicity. In addition, we summarized current research gaps and pointed out the future directions for research. The detailed information in this paper shows that the application and development of Omics techniques have significantly promoted the research on MCs toxicity, and it is also a valuable resource for exploring the toxic mechanism of MCs.