Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners. (June 2021)

• Record Type: Journal Article
• Authors: Molton, James S.; Lee, I. Russel; Bertrand, Denis; Ding, Ying; Kalimuddin, Shirin; Lye, David C.; Nagarajan, Niranjan; Gan, Yunn-Hwen; Archuleta, Sophia
• Is Part Of: International journal of infectious diseases. Volume 107(2021)
• Page Start: 1
• Page End: 4
• Publication Date: 2021-06
• Subjects: Klebsiella pneumoniae -- Liver abscess -- Microbiome -- Genomics; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2021.04.012
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: Clinical Klebsiella pneumoniae isolates from 24 patients with Klebsiella liver abscess were genotyped. The stool metagenomes of patients and their cohabiting domestic partners were analyzed. K. pneumoniae were identified in 33% of index patient stools. One index patient's clinical isolate was identified in their domestic partner's stool. This could represent a transmission event or exposure to a common environmental source. Abstract: Objectives: Hypermucoviscous Klebsiella pneumoniae is an emerging cause of community-acquired liver abscess. The aim of this study was to investigate whether hypermucoviscous strains could be shared among households. Methods: The clinical K. pneumoniae isolates from a cohort of 24 patients with Klebsiella liver abscess were genotyped, and the stool metagenomes of the index patients and their cohabiting domestic partners were analyzed. Results: K. pneumoniae was identified in 33% of index patient stools, and one index patient's clinical isolate was identified in their domestic partner's stool. Conclusions: This could represent a transmission event or could represent exposure to a common environmental source.