Plasma oxysterols: Altered level of plasma 24-hydroxycholesterol in patients with bipolar disorder. Issue 211 (July 2021)

• Record Type: Journal Article
• Authors: Guidara, Wassim; Messedi, Meriam; Maalej, Manel; Naifar, Manel; Khrouf, Walid; Grayaa, Sahar; Maalej, Mohamed; Bonnefont-Rousselot, Dominique; Lamari, Foudil; Ayadi, Fatma
• Is Part Of: Journal of steroid biochemistry and molecular biology. Issue 211(2021)
• Publication Date: 2021-07
• Subjects: Oxysterols -- 24-hydroxycholesterol -- 27-hydroxycholesterol -- Bipolar disorder -- Biomarker; Steroid hormones -- Periodicals; Biochemistry -- Periodicals; Hormones -- Periodicals; Molecular Biology -- Periodicals; Hormones stéroïdes -- Périodiques; Steroid hormones; Periodicals; 572.579
• DOI: 10.1016/j.jsbmb.2021.105902
• Languages: English
• ISSNs: 0960-0760

Abstract

Highlights: Profile of oxysterols is altered in drug free patient with bipolar disorder (BD). Compared to the control group, higher significance was observed for cholestane-3β, 5α, 6β-triol, 27-hydroxycholesterol (27−OHC) and Cholestanol in patients with BD. The concentration of 24-hydroxycholesterol (24−OHC) was significantly lower in patients compared to controls. 24−OHC was also negatively correlated to MAS subscale score. 24−OHC is an independent risk factor for BD. Abstract: Cholesterol and its oxygenated metabolites, including oxysterols, are intensively investigated as potential players in the pathophysiology of brain disorders. Altered oxysterol levels have been described in patients with numerous neuropsychiatric disorders. Recent studies have shown that Bipolar disorder (BD) is associated with the disruption of cholesterol metabolism. The present study was aimed at investigating the profile of oxysterols in plasma, their ratio to total cholesterol and their association with clinical parameters in patients with BD. Thirty three men diagnosed with BD and forty healthy controls matched for age and sex were included in the study. Oxysterol levels were measured by isotope-dilution ultra-performance liquid chromatography-tandem mass spectrometry. Significantly higher levels were observed for cholestane-3β, 5α, 6β-triol, 27-hydroxycholesterol (27−OHC) and Cholestanol in patients with BD. The concentration of 24-hydroxycholesterol (24−OHC) was significantly lower in patients compared to controls. 24−OHC was also negatively correlated to MAS subscale score (r =-0.343; p = 0.049). In patients, 24−OHC was inversely correlated with age (r = -0.240; p = 0.045). Multivariate analysis found that BD acute decompensation was independently related to the rise in plasma 24−OHC ( p = 0.002; OR = 0.966, 95 % CI [0.945 – 0.987]). However, the 24−OHC assay relevance as a biomarker of this disease deserves further investigation in other studies.