Sustainable Protocol for the Reduction of Nitroarenes by Heterogeneous Au@SBA‐15 with NaBH4 under Flow Conditions. Issue 13 (11th February 2019)

• Record Type: Journal Article
• Authors: Ferlin, Francesco; Giannoni, Tommaso; Zuliani, Alessio; Piermatti, Oriana; Luque, Rafael; Vaccaro, Luigi
• Is Part Of: ChemSusChem. Volume 12:Issue 13(2019)
• Page Start: 3178
• Page End: 3184
• Publication Date: 2019-02-11
• Subjects: flow conditions -- gold nanoparticles -- heterogeneous catalysis -- nitroarenes -- SBA-15; Green chemistry -- Periodicals; Sustainable engineering -- Periodicals; Chemistry -- Periodicals; Chemical engineering -- Periodicals; 660
• DOI: 10.1002/cssc.201802359
• Languages: English
• ISSNs: 1864-5631

Abstract

Abstract: A gold‐incorporated SBA‐15 catalyst was prepared by a solvent‐free ball‐milling approach. The catalyst showed high reactivity and selectivity in the reduction of a variety of nitroarenes to anilines operating in absolute EtOH with NaBH4 as reducing agent. The catalyst was reused in batch conditions over five consecutive runs without any losses of activity or selectivity. Considering the high chemical stability and reusability of the catalytic system, a continuous‐flow protocol was also investigated and defined to minimize the generation of waste and optimize the continuous reuse of the catalyst. Benefits of flow conditions were proven by turnover numbers that increased from 47.5 to 1902 and also by the minimization of both leaching (9.5 vs. 1 ppm) and E‐factor values (8 vs. 23 in batch). Abstract : All that is gold does glitter : Gold nanoparticles stabilized by SBA‐15 are prepared by a solvent‐free ball‐milling approach and show high reactivity and selectivity in the reduction of nitroarenes to anilines with NaBH4 as reducing agent. A continuous‐flow protocol is implemented to minimize waste generation and optimize reuse of the catalyst, with turnover numbers up to 1902.