Aqueous Ring‐Opening Polymerization‐Induced Self‐Assembly (ROPISA) of N‐Carboxyanhydrides. Issue 2 (22nd November 2019)

• Record Type: Journal Article
• Authors: Grazon, Chloé; Salas‐Ambrosio, Pedro; Ibarboure, Emmanuel; Buol, Alix; Garanger, Elisabeth; Grinstaff, Mark W.; Lecommandoux, Sébastien; Bonduelle, Colin
• Is Part Of: Angewandte Chemie international edition. Volume 59:Issue 2(2020)
• Page Start: 622
• Page End: 626
• Publication Date: 2019-11-22
• Subjects: amphiphiles -- polymerization -- self-assembly -- synthetic methods -- water; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201912028
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Reported here is the first aqueous ring‐opening polymerization (ROP) of N ‐carboxyanhydrides (NCAs) using α‐amino‐poly(ethylene oxide) as a macroinitiator to protect the NCA monomers from hydrolysis through spontaneous in situ self‐assembly (ISA). This ROPISA process affords well‐defined amphiphilic diblock copolymers that simultaneously form original needle‐like nanoparticles. Abstract : Sharp as a needle : Reported here is the first aqueous ring‐opening polymerization (ROP) of carboxyanhydrides (NCAs) using α‐amino‐poly(ethylene oxide) as the macroinitiator to protect NCA monomers from hydrolysis through spontaneous in situ self‐assembly (ISA). This ROPISA process affords well‐defined amphiphilic diblock copolymers that simultaneously form needle‐like nanoparticles.