Chemoenzymatic Halocyclization of γ, δ‐Unsaturated Carboxylic Acids and Alcohols. Issue 1 (22nd October 2019)

• Record Type: Journal Article
• Authors: Younes, Sabry H. H.; Tieves, Florian; Lan, Dongming; Wang, Yonghua; Süss, Philipp; Brundiek, Henrike; Wever, Ron; Hollmann, Frank
• Is Part Of: ChemSusChem. Volume 13:Issue 1(2020)
• Page Start: 97
• Page End: 101
• Publication Date: 2019-10-22
• Subjects: biocatalysis -- enzymes -- etherification -- lactones -- haloperoxidases; Green chemistry -- Periodicals; Sustainable engineering -- Periodicals; Chemistry -- Periodicals; Chemical engineering -- Periodicals; 660
• DOI: 10.1002/cssc.201902240
• Languages: English
• ISSNs: 1864-5631

Abstract

Abstract: A chemoenzymatic method for the halocyclization of unsaturated alcohols and acids by using the robust V‐dependent chloroperoxidase from Curvularia inaequalis ( Ci VCPO) as catalyst has been developed for the in situ generation of hypohalites. A broad range of halolactones and cyclic haloethers are formed with excellent performance of the biocatalyst. Abstract : You had me at "halo" : A chemoenzymatic method for the halocyclization of unsaturated alcohols and acids by using a robust V‐dependent chloroperoxidase as catalyst has been developed for the in situ generation of hypohalites. A broad range of halolactones and cyclic haloethers are formed with excellent biocatalyst performance.