Neurotoxicities associated with checkpoint inhibitors: Two case reports and a review of the literature. Issue 1 (26th November 2019)

• Record Type: Journal Article
• Authors: Cordes, Lisa M.; Davarpanah, Nicole N.; Reoma, Lauren B.; Gasmi, Billel; Quezado, Martha; Khan, Omar I.; Nath, Avindra; Apolo, Andrea B.
• Is Part Of: Clinical case reports. Volume 8:Issue 1(2020)
• Page Start: 24
• Page End: 32
• Publication Date: 2019-11-26
• Subjects: aseptic meningitis -- checkpoint inhibitor -- encephalitis -- ipilimumab -- neurotoxicity -- nivolumab; Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.2534
• Languages: English
• ISSNs: 2050-0904

Abstract

Abstract: We report a case of nivolumab‐induced delayed‐onset aseptic meningitis and a case of limbic encephalitis and peripheral nerve palsy with toxicity relapse 6 months after initial presentation. The atypical presentations contribute to our knowledge of these rare events and reinforce the necessity for vigilant monitoring and a multidisciplinary treatment approach. Abstract : We report a case of nivolumab‐induced delayed‐onset aseptic meningitis and a case of limbic encephalitis and peripheral nerve palsy with toxicity relapse 6 months after initial presentation. The atypical presentations contribute to our knowledge of these rare events and reinforce the necessity for vigilant monitoring and a multidisciplinary treatment approach.