Highly efficient and green synthesis of 2, 4-diphenyl substituted thiazoles. Issue 5 (3rd March 2020)

• Record Type: Journal Article
• Authors: Zhang, Jungan; Li, Peipei; Zeng, Hongyun; Huang, Yu; Hong, Wei
• Is Part Of: Synthetic communications. Volume 50:Issue 5(2020)
• Page Start: 735
• Page End: 741
• Publication Date: 2020-03-03
• Subjects: Cyclization -- cyclodextrin -- 24-diphenyl thiazoles -- green synthesis; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2020.1718711
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: 2, 4-Diphenyl thiazole is an important organic intermediate and its derivatives contain multiple biological properties. In the present study, we reported a new protocol to synthesize 2, 4-diphenyl thiazole analogs, which involved the bromination of ethyl benzoylacetates with NBS in the presence of 2-hydroxypropyl-β-cyclodextrin, followed by a direct cyclization with thiobenzamides in water. Compared with the reported method, the current protocol contains less reaction steps, milder reaction conditions, and simpler workup procedure. Graphical Abstract: