Helicobacter pylori infection and risk of preeclampsia: a systematic review and meta-analysis. (17th January 2019)

• Record Type: Journal Article
• Authors: Nourollahpour Shiadeh, Malihe; Riahi, Seyed Mohammad; Adam, Ishag; Saber, Vafa; Behboodi Moghadam, Zahra; Armon, Bahram; Spotin, Adel; Nazari Kangavari, Hajar; Rostami, Ali
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 32:Number 2(2019)
• Page Start: 324
• Page End: 331
• Publication Date: 2019-01-17
• Subjects: Helicobacter pylori -- cytotoxin-associated antigen A -- pregnant women -- preeclampsia; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2017.1378331
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective: Helicobacter pylori is associated with many pregnancy adverse effects such as preeclampsia (PE). We performed this systematic review and meta-analysis study to assess the possible association between H. pylori infection and PE and this is the first meta-analysis to clarify this issue. Methods: PubMed, ISI (Web of Science), SCOPUS, and Google Scholar databases were searched (up to April 2017) to identify the relevant studies. The Meta-analysis of Observational Studies in Epidemiology and Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines were used to do this study. Pooled odds ratio (OR) and 95% confidence intervals (CI) were estimated using a random-effects meta-analysis model. Heterogeneity was assessed with the χ 2 -based Q -test and I 2 statistic. Results: A total of eight studies including 889 participants (460 preeclamptic women and 429 controls) met the eligibility criteria. A positive association was found between H. pylori infection and PE (OR: 3.35; 95% CI: 2.21–5.10). Heterogeneity was acceptable (χ 2 = 13.39; I 2 = 47.7, 95% CI: 0–77). In subgroup analysis, cytotoxin-associated antigen A seropositivity was a substantial risk factor for PE when immunoblotting methods (OR: 11.12; 95% CI: 5.34–23.16; χ 2 = 6.42; I 2 = 53.3, 95% CI: 0–85) were used, whereas it was not potential risk factor for PE when ELISA was used as a detecting method (OR: 1.11; 95% CI: 0.6–2.06; χ 2 = 1.83; I 2 = 0, 95% CI: 0–90). Conclusions: This study indicated that women with H. pylori infection, especially those infected with Cag A positive strains are more likely to have PE compared with the uninfected women.