Breakthrough disseminated Saprochaete capitata infection in a child with acute myeloid leukaemia receiving caspofungin therapy. Issue 2 (June 2014)

• Record Type: Journal Article
• Authors: Purohit, Prashant; Al‐Obaid, Inam; Al‐Oneizi, Ebtesam; Al‐Hindi, Osama; Joseph, Leena; Ahmad, Suhail; Khan, Ziauddin
• Is Part Of: JMM case reports. Volume 1:Issue 2(2014)
• Publication Date: 2014-06
• Subjects: Breakthrough infection -- echinocandins -- fungaemia -- Saprochaete capitata; Medical microbiology -- Periodicals; 616.9041
• DOI: 10.1099/jmmcr.0.001750
• Languages: English
• ISSNs: 2053-3721

Abstract

Abstract : Introduction: We present a fatal case of disseminated infection in a child with leukaemia, caused by Saprochaete capitata, an ascomycetous yeast. Case presentation: The aetiological role of disseminated infection by S. capitata in a child with relapsed acute myeloid leukaemia following bone‐marrow transplantation was established by its repeated isolation from blood, tracheal secretion and urine samples. The identity of S. capitata was confirmed by phenotypic and molecular methods. The isolate showed reduced susceptibility to caspofungin. Conclusion: This report indicates that patients receiving echinocandin prophylaxis are at risk of breakthrough infections caused by S. capitata or other arthroconidial yeast species. To the best of our knowledge, this is the first well‐documented case of S. capitata infection from the Middle East.