Association of Copeptin With Sense of Coherence in Individuals With Varying Degrees of Glucose Intolerance. Issue 2 (February 2020)

• Record Type: Journal Article
• Authors: Madhu, Sri Venkata; Aslam, Mohammad; Siddiqui, Azaz Ahmad; Goyal, Sandeep; Mishra, Brijesh Kumar
• Is Part Of: Psychosomatic medicine. Volume 82:Issue 2(2020)
• Publication Date: 2020-02
• Subjects: arginine vasopressin -- copeptin -- diabetes -- glucose intolerance -- sense of coherence -- stress -- AVP = arginine-vasopressin -- CI = confidence interval -- CRH = corticotropin-releasing hormone -- HbA1c = glycated hemoglobin -- HPA axis = hypothalamic-pituitary-adrenal axis -- NDDM = newly detected diabetes mellitus -- NGT = normal glucose tolerance -- OR = odds ratio -- PDS = postdexamethasone suppression -- PSS = perceived stress scale -- SOC = sense of coherence; Medicine, Psychosomatic -- Periodicals; 616.0805
• DOI: 10.1097/PSY.0000000000000768
• Languages: English
• ISSNs: 0033-3174

Abstract

ABSTRACT: Objective: This study aimed to examine the association of serum copeptin levels, a surrogate marker of arginine-vasopressin secretion with sense of coherence (SOC) among individuals with varying degrees of glucose intolerance. Methods: The study was conducted in 120 age- and sex-matched individuals who were divided equally into three groups. Group A included individuals with normal glucose tolerance; group B, individuals with prediabetes (impaired glucose tolerance and/or impaired fasting glucose); and group C, individuals with newly detected diabetes mellitus (NDDM). SOC, perceived stress scale (PSS), copeptin, anthropometry, glycated hemoglobin, insulin, and salivary cortisol were measured in all study participants. Results: The SOC score was found to be significantly lower in group C compared with group A ( p < .001) and group B ( p = .006). The PSS score was found to be significantly higher in group C compared with group A ( p = .002). No significant difference was found between PSS scores of groups B and C ( p = .25). Copeptin levels were found to be significantly higher in group C compared with group A ( p = .016). Copeptin levels in group C did not differ significantly from those in group B ( p = .056). There was a significant negative correlation between serum copeptin levels and SOC in the NDDM group C ( r = 0.31, p = .048) and overall ( r = 0.19, p = .037). In multiple regression analysis, SOC emerged as the variable with the strongest association with 2-hour postprandial plasma glucose and glycated hemoglobin. Conclusion: Individuals with NDDM displayed significantly higher serum copeptin levels that inversely correlated with SOC, a global measure of stress coping ability.