Performance of B-mode ratio and 2D shear wave elastography for the detection and quantification of hepatic steatosis and fibrosis after liver transplantation. Issue 2 (February 2020)

• Record Type: Journal Article
• Authors: Dubois, Marine; Ronot, Maxime; Houssel-Debry, Pauline; Brun, Vanessa; Rayar, Michel; Auger, Magali; Beuzit, Luc; Turlin, Bruno; Aubé, Christophe; Paisant, Anita
• Is Part Of: European journal of gastroenterology & hepatology. Volume 32:Issue 2(2020)
• Publication Date: 2020-02
• Subjects: elastography -- fibrosis -- liver transplantation -- steatosis -- ultrasound; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Digestive organs -- Diseases; Liver -- Diseases; Periodicals; 616.33
• DOI: 10.1097/MEG.0000000000001500
• Languages: English
• ISSNs: 0954-691X

Abstract

Abstract : Objectives: To evaluate the diagnostic performance of B-mode ratio and shear wave elastography (SWE) for the assessment of steatosis and liver fibrosis after liver transplantation. Materials and methods: Patients hospitalized for a systematic check-up after liver transplantation underwent the same day hepatic ultrasound with B-mode ratio and SWE, followed by liver biopsy and biological examinations. Steatosis was measured using hepatorenal sonographic index of B-mode ratio and liver stiffness using SWE. Liver biopsy, used as gold standard, graded steatosis S0(<5%), S1(5–<33%), S2(33–<66%), or S3(≥66%) and liver fibrosis according to the Metavir score. The results were tested against two external validation cohorts. Results: Fifty-eight patients were included. Mean B-ratio value was significantly higher in patients with steatosis (0.95 ± 0.13 versus 1.39 ± 0.41, P < 0.001). A B-mode ratio cutoff values at least 0.985 was found optimal for steatosis' detection [area under the receiver operating characteristic curve (AUROC) 0.902 ± 0.05, sensitivity 95%, specificity 79%]. A B-mode ratio value below 0.9 ruled out steatosis and above 1.12 ruled in steatosis. Mean SWE value for patients without significant fibrosis (⩽F1) was 15.90 ± 9.2 versus 19.27 ± 7.7 kPa for patients with fibrosis ( P = 0.185). A 2D-SWE value below 7.85 kPa ruled out significant fibrosis and above 26.35 kPa ruled it in. Conclusion: The B-mode ratio is an efficient and accurate tool for the noninvasive diagnostic of steatosis in postliver transplantation patients. Yet, because liver stiffness is higher in postliver transplantation patients, 2D-SWE is not reliable in the diagnosis of significant fibrosis after liver transplantation.