18F-FDG PET/CT-Guided Diagnosis and Evaluation of Treatment Response to Cyclosporine A in Maldistributed Subcutaneous Panniculitis-like T-Cell Lymphoma Without Typical Skin Rash. (February 2020)

• Record Type: Journal Article
• Authors: Abe, Yoshiaki; Narita, Kentaro; Kobayashi, Hiroki; Kitadate, Akihiro; Takeuchi, Masami; Matsue, Kosei
• Is Part Of: Clinical nuclear medicine. Volume 45:Number 2(2020)
• Publication Date: 2020-02
• Subjects: cyclosporine A -- diagnosis -- FDG PET/CT -- subcutaneous panniculitis-like T-cell lymphoma; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000002863
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: A 30-year-old woman presented with persistent fever and elevated lactate dehydrogenase levels without skin rash. 18 F-FDG PET/CT revealed FDG uptake in subcutaneous tissues in the forearm, buttocks, and lower limbs, whereas the trunk was unaffected. She was diagnosed with subcutaneous panniculitis-like T-cell lymphoma based on a PET/CT-guided subcutaneous tissue biopsy from the thigh. Although conventional cytotoxic agent–based chemotherapies failed to achieve disease remission, subsequent cyclosporine A treatment promptly resolved the fever and laboratory abnormalities. Remarkably, abnormal FDG uptake disappeared entirely on follow-up PET/CT, demonstrating its utility in the evaluations of responses to emerging cyclosporine A–based treatments in subcutaneous panniculitis-like T-cell lymphoma.