18F-PSMA 1007 Uptake in Brain Metastases From Breast Cancer. (February 2020)

• Record Type: Journal Article
• Authors: Marafi, Fahad; Sasikumar, Arun; Alfeeli, Mahmoud; Fathallah, Wael
• Is Part Of: Clinical nuclear medicine. Volume 45:Number 2(2020)
• Publication Date: 2020-02
• Subjects: 18F-PSMA 1007 -- brain metastases -- breast cancer; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000002821
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: A 64-year-old woman with metastatic breast cancer on follow-up had suspicious recurrent brain metastases. She underwent 18 F-FDG PET/CT, 18 F-PSMA 1007 brain PET/CT, and brain MRI. 18 F-PSMA 1007 showed intense tracer localization in the suspected recurrent brain metastasis in right parietal lobe and also picked up 2 more metastatic brain lesions, which had concurrent findings of metastasis in subsequent MRI. Our case highlights the feasibility of 18 F-PSMA 1007 PET/CT imaging of brain metastases from nonprostate cancers. It may be used as surrogate imaging tracer for potential theranostic application using alpha or beta emitters considering its similarity to PSMA-617.