Raynaud's phenomenon and antiphospholipid antibodies in systemic lupus erythematosus: is there an association?. Issue 10 (12th September 2003)

• Record Type: Journal Article
• Authors: Caccavo, D; Del Porto, F; Garzia, P; Mitterhofer, A P; Galluzzo, S; Rigon, A; Vadacca, M; Navajas, M F; Amoroso, A; Afeltra, A
• Is Part Of: Annals of the rheumatic diseases. Volume 62:Issue 10(2003)
• Page Start: 1003
• Page End: 1005
• Publication Date: 2003-09-12
• Subjects: antiphospholipid antibodies -- Raynaud's phenomenon -- systemic lupus erythematosus; aβ2GPI, anti-β2-glycoprotein I antibodies -- aCL, anticardiolipin antibodies -- aPA, antiphosphatidic acid antibodies -- aPI, antiphosphatidylinositol antibodies -- aPL, antiphospholipid antibodies -- aPS, antiphosphatidylserine antibodies -- CTD, connective tissue diseases -- RP, Raynaud's phenomenon -- SLE, systemic lupus erythematosus; Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.62.10.1003
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Objective: To evaluate the association of IgG and IgM antibodies directed against different negatively charged phospholipids (that is, anticardiolipin (aCL), antiphosphatidylinositol, antiphosphatidylserine, and antiphosphatidic acid) and anti-β2 -glycoprotein I (aβ2 GPI), with Raynaud's phenomenon in patients with systemic lupus erythematosus (SLE). Methods: Ninety three patients with SLE (81 female), 40 with and 53 without Raynaud's phenomenon, were included in the study. IgG and IgM antiphospholipid antibodies and aβ2 GPI were determined by enzyme linked immunosorbent assay (ELISA). Results: Fifty patients (54%) were positive for IgG and/or IgM antibodies to one or more phospholipid antigens or to β2 GPI. The prevalence of all autoantibodies evaluated, either IgG or IgM, was higher in patients without than in those with Raynaud's phenomenon. A negative association was found between IgG aCL and Raynaud's phenomenon (p=0.038), whereas autoantibodies other than aCL were not significantly associated with Raynaud's phenomenon. Conclusion: Our results demonstrate no positive association between antiphospholipid antibodies and Raynaud's phenomenon in SLE and indicate that measurement of anti-negatively charged phospholipid antibodies other than aCL is not useful as a serological marker predictive for Raynaud's phenomenon.