Innate Immune Regulation by Toll-Like Receptors in the Brain. (14th October 2012)

• Record Type: Journal Article
• Authors: Mallard, Carina
• Other Names: Martinuzzi A. Academic Editor.; Moreno-López B. Academic Editor.
• Is Part Of: ISRN neurology. Volume 2012(2012)
• Publication Date: 2012-10-14
• Subjects: Neurology -- Periodicals; Nervous System Diseases; Neurology; Neurology; Periodicals; 616.8
• DOI: 10.5402/2012/701950
• Languages: English
• ISSNs: 2090-5505

Abstract

Abstract : The innate immune system plays an important role in cerebral health and disease. In recent years the role of innate immune regulation by toll-like receptors in the brain has been highlighted. In this paper the expression of toll-like receptors and endogenous toll-like receptor ligands in the brain and their role in cerebral ischemia will be discussed. Further, the ability of systemic toll-like receptor ligands to induce cerebral inflammation will be reviewed. Finally, the capacity of toll-like receptors to both increase (sensitization) and decrease (preconditioning/tolerance) the vulnerability of the brain to damage will be disclosed. Studies investigating the role of toll-like receptors in the developing brain will be emphasized.