Differentiation between 6- and 7-Membered Rings Based on Theoretical Calculation of NMR Parameters. (14th November 2012)

• Record Type: Journal Article
• Authors: Klika, Karel D.
• Other Names: Casado J. Academic Editor.; Choi J.-H. Academic Editor.; Ferri D. Academic Editor.; Gerothanassis I. P. Academic Editor.; Kumar G. S. Academic Editor.; Saniger J. M. Academic Editor.
• Is Part Of: ISRN spectroscopy. Volume 2012(2012)
• Publication Date: 2012-11-14
• Subjects: Spectrum analysis -- Periodicals; Spectrum analysis; Periodicals; Electronic journals; 543.5
• DOI: 10.5402/2012/697156
• Languages: English
• ISSNs: 2090-8776

Abstract

Abstract : The determination of ring size can vary from simple to complex, but the process in difficult cases can be advantageously augmented by DFT calculation of NMR parameters such as the chemical shifts of H 1 (δ H ), C 13 (δ C ), and other nuclei as well as pertinent spin-spin (scalar) coupling constants, for example, those between protons (J H, H ). Differentiation between 6- and 7-membered ring formation in the case of 3, 4-dihydro-2 H -3-hydroxymethyl-1, 4-benzoxazine and 2, 3, 4, 5-tetrahydro-1, 5-benzoxazepine-3-ol was evaluated with a view to not only affecting 6- versus 7-membered ring differentiation generally for cases on hand, but also in the case of literature reports where the assigned structures may be in doubt. Thus, the main focus was on the usually reported NMR parameters of δ H, δ C, andJ H, H and wherein the analysis was found to be highly successful, particularly for δ C, and thus potentially amenable for broad application.