Decreased Nucleus Accumbens Connectivity at Rest in Medication-Free Patients with Obsessive-Compulsive Disorder. (1st June 2021)

• Record Type: Journal Article
• Authors: Chen, Yunhui; Ou, Yangpan; Lv, Dan; Ma, Jidong; Zhan, Chuang; Yang, Ru; Jia, Cuicui; Shang, Tinghuizi; Sun, Lei; Wang, Yuhua; Sun, Zhenghai; Zhang, Guangfeng; Wang, Xiaoping; Guo, Wenbin; Li, Ping
• Other Names: Wyss J. Michael Academic Editor.
• Is Part Of: Neural plasticity. Volume 2021(2021)
• Publication Date: 2021-06-01
• Subjects: Neuroplasticity -- Periodicals; 612.82
• DOI: 10.1155/2021/9966378
• Languages: English
• ISSNs: 2090-5904

Abstract

Abstract : Background. Patients with obsessive-compulsive disorder (OCD) experience deficiencies in reward processing. The investigation of the reward circuit and its essential connectivity may further clarify the pathogenesis of OCD. Methods. The current research was designed to analyze the nucleus accumbens (NAc) functional connectivity at rest in medicine-free patients with OCD. Forty medication-free patients and 38 gender-, education-, and age-matched healthy controls (HCs) were recruited for resting-state functional magnetic resonance imaging. Seed-based functional connectivity (FC) was used to analyze the data. LIBSVM (library for support vector machines) was designed to identify whether altered FC could be applied to differentiate OCD. Results. Patients with OCD showed remarkably decreased FC values between the left NAc and the bilateral orbitofrontal cortex (OFC) and bilateral medial prefrontal cortex (MPFC) and between the right NAc and the left OFC at rest in the reward circuit. Moreover, decreased left NAc-bilateral MPFC connectivity can be deemed as a potential biomarker to differentiate OCD from HCs with a sensitivity of 80.00% and a specificity of 76.32%. Conclusion. The current results emphasize the importance of the reward circuit in the pathogenesis of OCD.