Prognostic Value of the Red Cell Distribution Width in Patients with Sepsis-Induced Acute Respiratory Distress Syndrome: A Retrospective Cohort Study. (2nd June 2021) - Wang, Huabin
Abstract : Objective . The prognostic value of the red cell distribution width (RDW) in patients with sepsis-induced acute respiratory distress syndrome (ARDS) is still elusive. This study is aimed at determining whether RDW is a prognostic indicator of sepsis-induced ARDS. Methods. This retrospective cohort study included 1161 patients with sepsis-induced ARDS. The datasets were acquired from the Medical Information Mart for Intensive Care III database. The locally weighted scatter-plot smoothing technique, Cox regression, Kaplan-Meier estimator, and subgroup analysis were carried out to evaluate the association between RDW and 90-day mortality. Results. The RDW and mortality had a roughly linear increasing relationship. The Cox regression model results were as follows: for level 2 (14.5 % < RDW < 16.2 % ), hazard ratio HR = 1.35, 95% confidence interval CI = 1.03 – 1.77, and for level 3 (RDW ≥ 16.2 % ), HR = 2.07, 95% CI = 1.59 – 2.69 . The following results were obtained when RDW was treated as a continuous variable: HR = 1.11, 95 % CI = 1.06 – 1.15 . The P values of the interaction between the RDW and covariates were greater than 0.05. Conclusion. RDW is a new independent prognostic marker for patients with sepsis-induced ARDS.