Estrogens as Antioxidant Modulators in Human Fertility. (20th November 2013)

• Record Type: Journal Article
• Authors: Mancini, A.; Raimondo, S.; Persano, M.; Di Segni, C.; Cammarano, M.; Gadotti, G.; Silvestrini, A.; Pontecorvi, A.; Meucci, E.
• Other Names: Dufau Maria L. Academic Editor.
• Is Part Of: International journal of endocrinology. Volume 2013(2013)
• Publication Date: 2013-11-20
• Subjects: Endocrinology -- Periodicals; Endocrinology; Endocrinology -- Periodicals; Endocrine System Diseases -- Periodicals; Periodicals; 616.4
• DOI: 10.1155/2013/607939
• Languages: English
• ISSNs: 1687-8337

Abstract

Abstract : Among treatments proposed for idiopathic male infertility, antiestrogens, like tamoxifen, play a possible role. On the other hand, oxidative stress is a mechanism well recognized for deleterious effects on spermatozoa function. After reviewing the literature on the effects of estrogens in modulation of antioxidant systems, in both sexes, and in different in vivo and in vitro models, we suggest, also on the basis of personal data, that a tamoxifen treatment could be active via an increase in seminal antioxidants.