Relationship between Serum Levels of OPG and TGF-β with Decreasing Rate of BMD in Native Chinese Women. (29th January 2013)

• Record Type: Journal Article
• Authors: Wu, Xi-Yu; Peng, Yi-Qun; Zhang, Hong; Xie, Hui; Sheng, Zhi-Feng; Luo, Xiang-Hang; Dai, Ru-Chun; Zhou, Hou-De; Wu, Xian-Ping; Liao, Er-Yuan
• Other Names: Xiang Guang-Da Academic Editor.
• Is Part Of: International journal of endocrinology. Volume 2013(2013)
• Publication Date: 2013-01-29
• Subjects: Endocrinology -- Periodicals; Endocrinology; Endocrinology -- Periodicals; Endocrine System Diseases -- Periodicals; Periodicals; 616.4
• DOI: 10.1155/2013/727164
• Languages: English
• ISSNs: 1687-8337

Abstract

Abstract : The objective of this study was to investigate the relationship between serum levels of OPG, TGF- β 1, and TGF- β 2 and BMD decrease rate (BDR) in native Chinese women. This cross-sectional study was performed on 465 healthy native Chinese women aged 35–80 years. Serum levels of OPG, TGF- β 1, and TGF- β 2 were determined. BDR was measured by DXA at the posteroanterior spine, hip, and distal forearm. At all skeletal sites tested, there was a negative correlation between BDR and serum levels of both OPG (r = − 0.122 to –0.230, all P = 0.007–0.000) and TGF- β 2 (r = − 0.100 to –0.173, all P = 0.029–0.000) and a positive correlation between BDR and serum TGF- β 1 (r = 0.245 − 0.365, all P = 0.000 ). After adjustment for age and BMI, there were no statistically significant correlations between serum levels of OPG or TGF- β 2 and BDR. However, statistically significant correlations between serum TGF- β 1 and BDR at the lumbar spine and ultradistal forearm remained. Multiple linear regression stepwise analysis showed that serum OPG could explain 1.4–3.7% of BDR variation. Serum TGF- β 1 was a positive determinant of BDR and could explain 5.3–13.3% of BDR variation.