Matrix-induced autologous chondrocyte implantation versus autologous matrix-induced chondrogenesis for chondral defects of the talus: a systematic review. Issue 1 (3rd May 2021)

• Record Type: Journal Article
• Authors: Migliorini, Filippo; Maffulli, Nicola; Baroncini, Alice; Knobe, Matthias; Tingart, Markus; Eschweiler, Jörg
• Is Part Of: British medical bulletin. Volume 138:Issue 1(2021)
• Page Start: 144
• Page End: 154
• Publication Date: 2021-05-03
• Subjects: talus -- chondral defect -- mACI -- AMIC; Medicine -- Periodicals; 610.5
• DOI: 10.1093/bmb/ldab008
• Languages: English
• ISSNs: 0007-1420

Abstract

Abstract: Introduction: Chondral defects of the talus are common and their treatment is challenging. Source of data: Recent published literatures. Areas of agreement: Membrane-induced Autologous Chondrocyte Implantation (mACI) and Autologous Matrix-Induced Chondrogenesis (AMIC) have been proposed as management for chondral defects of the talus. Areas of controversy: It is debated whether AMIC provides greater outcomes compared to mACI for chondral regeneration. Several clinical studies showed controversial results, and the best treatment has not yet been clarified. Growing points: To investigate whether AMIC provide superior outcomes than mACI at midterm follow-up. Areas timely for developing research: AMIC exhibits similar clinical results to mACI. However, AMIC involves one single surgical procedure, no articular cartilage harvest and hence no morbidity from it, no need for chondrocyte expansion in a separate laboratory setting. For these reasons, AMIC may be preferred to mACI.