Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient. (July 2019)

• Record Type: Journal Article
• Authors: Ramdhan, N.D.; Blom, J.; Sutcliffe, I.C.; Pereira-Ribeiro, P.M.A.; Santos, C.S.; Mattos-Guaraldi, A.L.; Burkovski, A.; Sangal, V.
• Is Part Of: New microbes and new infections. Volume 30(2019)
• Publication Date: 2019-07
• Subjects: Adenoid cystic carcinoma -- Corynebacterium diphtheriae -- invasive infection -- nontoxigenic -- virulence; Medical microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Communicable Diseases -- Periodicals; Infection -- Periodicals; 616.9041
• DOI: 10.1016/j.nmni.2019.100544
• Languages: English
• ISSNs: 2052-2975

Abstract

Abstract: The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD -type and spaH -type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics.