Bariatric surgery is associated with increased risk of new‐onset inflammatory bowel disease: case series and national database study. Issue 8 (7th March 2018)

• Record Type: Journal Article
• Authors: Ungaro, R.; Fausel, R.; Chang, H. L.; Chang, S.; Chen, L. A.; Nakad, A.; El Nawar, A.; Prytz Berset, I.; Axelrad, J.; Lawlor, G.; Atreja, A.; Roque Ramos, L.; Torres, J.; Colombel, J.‐F.
• Is Part Of: Alimentary pharmacology & therapeutics. Volume 47:Issue 8(2018)
• Page Start: 1126
• Page End: 1134
• Publication Date: 2018-03-07
• Subjects: Digestive organs -- Diseases -- Treatment -- Periodicals; Digestive organs -- Effect of drugs on -- Periodicals; Gastrointestinal system -- Diseases -- Treatment -- Periodicals; Gastrointestinal system -- Effect of drugs on -- Periodicals; 615.73
• DOI: 10.1111/apt.14569
• Languages: English
• ISSNs: 0269-2813

Abstract

Summary: Background: Case series suggest a possible association between bariatric surgery and incident IBD. Aim: The aim of this study was to evaluate the association between bariatric surgery and new‐onset IBD. Methods: We first conducted a multi‐institutional case series of patients with a history of IBD and bariatric surgery. We next conducted a matched case‐control study using medical and pharmacy claims from 2008 to 2012 in a US national database from Source Healthcare Analytics LLC. Bariatric surgery was defined by ICD‐9 or CPT code. Bariatric surgery was evaluated as recent (code in database timeframe), past (past history V code) or no history. Conditional logistic regression was used to estimate odds ratios (OR) and 95% CI for new‐onset IBD, CD and UC. Results: A total of 15 cases of IBD (10 CD, 4 UC, 1 IBD, type unclassified) with a prior history of bariatric surgery were identified. Most cases were women, had Roux‐en‐Y surgery years prior to diagnosis and few IBD‐related complications. A total of 8980 cases and 43 059 controls were included in our database analysis. Adjusting for confounders, a past history of bariatric surgery was associated with an increased risk of new‐onset IBD (OR 1.93, 95% CI 1.34‐2.79). However, patients who had recent bariatric surgery did not appear to be at shorter term risk of IBD (OR 0.94, 95% CI 0.58‐1.52). Conclusion: New‐onset IBD was significantly associated with a past history of bariatric surgery. This potential association needs to be confirmed in future prospective studies. Abstract : Linked Content This article is linked to Alukaidey and Heerasing, and Ungaro and Colombel papers. To view these articles visit https://doi.org/10.1111/apt.14611 and https://doi.org/10.1111/apt.14667 .