Diurnal rodents as pertinent animal models of human retinal physiology and pathology. (January 2020)

• Record Type: Journal Article
• Authors: Verra, Daniela M.; Sajdak, Benjamin S.; Merriman, Dana K.; Hicks, David
• Is Part Of: Progress in retinal and eye research. Volume 74(2020:Jan.)
• Publication Date: 2020-01
• Subjects: Retina -- Periodicals; Retina -- Research -- Methodology -- Periodicals; Eye -- Diseases -- Periodicals; Eye -- Periodicals; Eye Diseases -- Periodicals; Retina -- Periodicals; Rétine -- Périodiques; Rétine -- Recherche -- Méthodologie -- Périodiques; 617.7005
• DOI: 10.1016/j.preteyeres.2019.100776
• Languages: English
• ISSNs: 1350-9462

Abstract

Abstract: This presentation will survey the retinal architecture, advantages, and limitations of several lesser-known rodent species that provide a useful diurnal complement to rats and mice. These diurnal rodents also possess unusually cone-rich photoreceptor mosaics that facilitate the study of cone cells and pathways. Species to be presented include principally the Sudanian Unstriped Grass Rat and Nile Rat ( Arvicanthis spp .), the Fat Sand Rat ( Psammomys obesus ), the degu ( Octodon degus ) and the 13-lined ground squirrel ( Ictidomys tridecemlineatus ). The retina and optic nerve in several of these species demonstrate unusual resilience in the face of neuronal injury, itself an interesting phenomenon with potential translational value.