4D flow MRI versus conventional 2D for measuring pulmonary flow after Tetralogy of Fallot repair. (1st February 2020)

• Record Type: Journal Article
• Authors: Isorni, M.A.; Martins, D.; Ben Moussa, N.; Monnot, S.; Boddaert, N.; Bonnet, D.; Hascoet, S.; Raimondi, F.
• Is Part Of: International journal of cardiology. Volume 300(2020)
• Page Start: 132
• Page End: 136
• Publication Date: 2020-02-01
• Subjects: Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2019.10.030
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: After tetralogy of Fallot (TOF) repair, pulmonary regurgitation and right ventricular function must be monitored. Conventional (2D) cardiac magnetic resonance (CMR) is currently the clinical reference method for measuring pulmonary regurgitation. However, 4DFlow CMR has been reported to provide a more comprehensive flow analysis than 2D CMR. We aimed to compare 4DFlow CMR to 2D CMR for assessing pulmonary regurgitation and flow, as well as aortic flow, in children and adults after surgical repair of TOF. Methods: Retrospective analysis of patients with repaired TOF admitted for cardiac MRI with 4DFlow acquisition from 2016 to 2018. Linear regression was used to assess correlations and Bland-Altman analyses were performed. Results: The 60 included patients had a mean age of 18.2 ± 10.4 years (range, 2–54 years). Significant correlations between the two techniques were found for pulmonary regurgitant fraction (R [2] = 0.6642, p < 0.0001), net pulmonary flow (R [2] = 0.6782, p < 0.0001), forward pulmonary flow (R [2] = 0.6185, p < 0.0001), backward pulmonary flow (R [2] = 0.8192, p < 0.0001), and aortic valve flow (R [2] = 0.6494, p < 0.0001). The Bland-Altman analysis showed no significant bias, narrow limits of agreement, and few scattered points. The correlation between pulmonary and aortic flow was better with 4DFlow CMR than with 2D CMR (R [2] = 0.8564, p < 0.0001 versus R [2] = 0.4393, p < 0, 0001, respectively). Interobserver reliability was good. Conclusion: These results establish the feasibility and reliability of 4DFlow CMR for assessing pulmonary flow in a large paediatric and adult population with repaired TOF. 4DFlow CMR may be more reliable than 2D MRI for pulmonary flow assessment after TOF repair. Highlights: 4D flow MRI for evaluation of pulmonary regurgitation is a reliable technique compared to 2D flow phase contrast technique. It has an high reproducibility and high internal consistency with possibility of extensive off line analysis. 4D flow MRI couple anatomic and functional analysis, providing a comprehensive data set after Tetralogy of Fallot repair.