Subclass distribution of low‐density lipoprotein triglyceride and the clustering of metabolic syndrome components in Japanese children. Issue 6 (26th May 2021)

• Record Type: Journal Article
• Authors: Tonouchi, Ryousuke; Okada, Tomoo; Abe, Yuriko; Kazama, Minako; Kuromori, Yuki; Yoshino, Yayoi; Iwata, Fujihiko; Hara, Mitsuhiko; Saito, Emiko; Morioka, Ichiro
• Is Part Of: Pediatrics international. Volume 63:Issue 6(2021)
• Page Start: 664
• Page End: 670
• Publication Date: 2021-05-26
• Subjects: child -- insulin resistance -- LDL subclasss -- low‐density lipoprotein triglyceride -- metabolic syndrome; Pediatrics -- Periodicals; 618.92
• DOI: 10.1111/ped.14490
• Languages: English
• ISSNs: 1328-8067

Abstract

Abstract: Background: Recent studies demonstrated that low‐density lipoprotein‐tryglyceride (LDL‐TG) may represent another marker of cardiovascular risks. We therefore measured LDL‐TG including the low‐density lipoprotein (LDL) subclass distribution and investigated the association between LDL‐TG subclass profile and the clustering of metabolic syndrome (MetS) components and insulin resistance in Japanese children. Methods: The study included 237 schoolchildren (boys 115, girls 122). Four subclasses of low‐density lipoprotein‐tryglyceride (large, medium, small, and very small) was quantified using high‐performance liquid chromatography. Total LDL‐TG and TG levels in LDL subclasses were evaluated among four MetS component groups; non‐abdominal obesity, abdominal obesity, pre‐MetS, and MetS. Results: Total LDL‐TG ( P = 0.0003, P = 0.0175) and triglyceride levels in LDL subclasses were significantly different among four MetS component groups (large: P = 0.0002, P = 0.0084; medium: P = 0.0009, P = 0.0491; small: P =0.0025, P = 0.0509; very small: P = 0.0808, P = 0.0228; boys and girls, respectively). Total LDL‐TG ( r = 0.411, P < 0.0001, r = 0.378. P < 0.0001) and triglyceride levels in LDL subclasses correlated positively with the homeostasis model of assessment ratio (large: r = 0.396, P < 0.0001, r = 0.346, P < 0.0001; medium: r = 0.274, P = 0.0030, r = 0.228, P = 0.0115; small: r = 0.342, P = 0.0002, r = 0.292, P = 0.0011; very small: r = 0.385, P < 0.0001, r = 0.426, P < 0.0001, boys and girls, respectively). Conclusions: Subclass distribution of LDL‐TG was significantly associated with the clustering of MetS components in both sexes, and insulin resistance is a significant determinant of LDL‐TG in all LDL subclasses. Lipoprotein‐tryglyceride subclass analysis, rather than LDL‐C, may provide a precise evaluation for cardiovascular disease risks in children with MetS.