Production of biodegradable rods of polycaprolactone/olanzapine for potential application in treatment of Schizophrenia. Issue 37 (1st May 2021)

• Record Type: Journal Article
• Authors: de Almeida, Hellen Regina Oliveira; de Carvalho Patricio, Beatriz Ferreira; do Anjos Garcia, Yasmin; da Silva, Talita Goulart; Pereira, Debora Baptista; Sarcinelli, Michelle Alvares; Rocha, Helvécio Vinícius Antunes; Mendonça, Roberta Helena
• Is Part Of: Journal of applied polymer science. Volume 138:Issue 37(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-05-01
• Subjects: biodegradable -- biomaterials -- drug delivery systems -- extrusion -- manufacturing; Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.50944
• Languages: English
• ISSNs: 0021-8995

Abstract

Abstract: Olanzapine (OLZ) is a commonly antipsychotic used to treat schizophrenia, a mental illness, with fewer side effects when compared with other drugs of the same class. It is commercialized mainly as oral tablets and orally disintegrating tablets. However, this drug oral bioavailability is affected by the first pass effect and low solubility in water. This requires high daily doses that can cause more side effects and poor treatment compliance. Also, the frequency of frequency of tablet intake is commonly related to patients' abandonment of schizophrenia treatment. So, the development of implantable biomaterials for OLZ delivery can be an alternative to solve both problems, since this material can, potentially, be used subcutaneously in less frequent administrations, thus the treatment has a greater chance of success. Therefore, the objective of this work was to produce polycaprolactone (PCL) rods incorporated with OLZ by hot‐melt extrusion technique. The rods were characterized by different techniques, which showed an amount of 6.78 ± 0.56 mg of OLZ per rod. The in vitro release studies were performed and they showed a controlled release of the drug that followed the Higuchi's model. These results indicated that the PCL/OLZ rods have potential application in the schizophrenia treatment. Abstract : Olanzapine (OLZ) is a commonly antipsychotic used to treat schizophrenia, this drug oral bioavailability is affected by the first pass effect and low solubility in water. Thus, potentially, implatable Olanzapine (OLZ)/ PCL rods were produced by extrusion technique. The in vitro release studies showed a controlled release of the drug that followed the Higuchi's model. These results indicated that the PCL/OLZ rods have potential application in the schizophrenia treatment.