Effects of phytochemicals on macrophage cholesterol efflux capacity: Impact on atherosclerosis. (19th January 2021)

• Record Type: Journal Article
• Authors: Soltani, Saba; Boozari, Motahareh; Cicero, Arrigo F. G.; Jamialahmadi, Tannaz; Sahebkar, Amirhossein
• Is Part Of: Phytotherapy research. Volume 35:Number 6(2021)
• Page Start: 2854
• Page End: 2878
• Publication Date: 2021-01-19
• Subjects: atherosclerosis -- cholesterol efflux capacity -- HDL cholesterol -- lipoproteins -- phytochemicals; Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.6991
• Languages: English
• ISSNs: 0951-418X

Abstract

Abstract : High‐density lipoprotein cholesterol (HDL) is the major promoter of reverse cholesterol transport and efflux of excess cellular cholesterol. The functions of HDL, such as cholesterol efflux, are associated with cardiovascular disease rather than HDL levels. We have reviewed the evidence base on the major classes of phytochemicals, including polyphenols, alkaloids, carotenoids, phytosterols, and fatty acids, and their effects on macrophage cholesterol efflux and its major pathways. Phytochemicals show the potential to improve the efficiency of each of these pathways. The findings are mainly in preclinical studies, and more clinical research is warranted in this area to develop novel clinical applications.