Red meat consumption, cooking mutagens, NAT1/2 genotypes and pancreatic cancer risk in two ethnically diverse prospective cohorts. Issue 4 (23rd April 2021)

• Record Type: Journal Article
• Authors: Huang, Brian Z.; Wang, Songren; Bogumil, David; Wilkens, Lynne R.; Wu, Lang; Blot, William J.; Zheng, Wei; Shu, Xiao‐Ou; Pandol, Stephen J.; Le Marchand, Loïc; Setiawan, Veronica Wendy
• Is Part Of: International journal of cancer. Volume 149:Issue 4(2021)
• Page Start: 811
• Page End: 819
• Publication Date: 2021-04-23
• Subjects: cohort -- diet -- epidemiology -- pancreatic ductal adenocarcinoma; Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.33598
• Languages: English
• ISSNs: 0020-7136

Abstract

Abstract: There is limited evidence on the association between red meat consumption and pancreatic cancer among ethnic minorities. We assessed this relationship in two large prospective cohorts: the Multiethnic Cohort Study (MEC) and the Southern Community Cohort Study (SCCS). Demographic, dietary and other risk factor data were collected at cohort entry. Red meat intake was assessed using cohort‐specific validated food frequency questionnaires. Incident pancreatic cancer cases were identified via linkages to state cancer registries. Cox regression was used to calculate relative risks (RRs) and 95% confidence intervals (CIs) for the association of red meat intake with pancreatic cancer risk in each cohort. We performed additional analyses to evaluate cooking methods, mutagens and effect modification by NAT1/2 genotypes. From a total of 184 542 (MEC) and 66 793 (SCCS) at‐risk participants, we identified 1618 (MEC) and 266 (SCCS) incident pancreatic cancer cases. Red meat consumption was associated with pancreatic cancer risk in the MEC (RRQ4vsQ1 1.18, 95% CI 1.02‐1.37) and with borderline statistical significance in the SCCS (RRQ4vsQ1 1.31, 95% CI 0.93‐1.86). This association was significant in African Americans (RRQ4vsQ1 1.49, 95% CI 1.06‐2.11) and Latinos (RRQ4vsQ1 1.44, 95% CI 1.02‐2.04) in the MEC, and among African Americans (RRQ4vsQ1 1.55, 95% CI 1.03‐2.33) in the SCCS. NAT2 genotypes appeared to modify the relationship between red meat and pancreatic cancer in the MEC ( p interaction = 0.03). Our findings suggest that the associations for red meat may be strongest in African Americans and Latinos. The mechanisms underlying the increased risk for these populations should be further investigated. Abstract : What's new? Studies in white populations indicate that eating red meat may boost pancreatic cancer risk. These authors investigated this association in ethnic minorities in the US. They also looked at cooking methods, mutagens such as heterocyclic aromatic amines (HAAs), and genetic variants in the enzymes N‐acetyltransferase 1/2 (NAT1/2), which impact a person's ability to neutralize these mutagens. By analyzing data from two large ethnically diverse cohorts, they found a significant association between red meat consumption and pancreatic cancer in African Americans and Latinos. They also found that NAT2 genotypes may play a role in this association.