A GalNAc/Gal-specific lectin modulates immune responses via toll-like receptor 4 independently of carbohydrate-binding ability. Issue 50 (1st June 2021)

• Record Type: Journal Article
• Authors: Chen, Shin-Tai; Liao, Jiahn-Haur; Huang, Kai-Fa; Lee, I-Ming; Wong, Wei-Ting; Wu, Shih-Hsiung; Hua, Kuo-Feng
• Is Part Of: Chemical communications. Volume 57:Issue 50(2021)
• Page Start: 6209
• Page End: 6212
• Publication Date: 2021-06-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc01834e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A CGL-TLR4/MD2 binding model reveals that Crenomytilus grayanus lectin (CGL) modulates immunity independently of sugar-binding activity and conventional MD2 binding pocket. Abstract : Toll-like receptor 4 (TLR4) recognizes various protein ligands; however, the protein-TLR4 binding model is unclear. Here we demonstrate a Crenomytilus grayanus lectin (CGL)-TLR4/MD2 model to show that CGL interacts with a TLR4/myeloid differentiation factor 2 (MD2) complex independently of sugar-binding properties. CGL could suppress lipopolysaccharide-induced immune responses significantly, suggesting that TLR4 itself has potential as a therapeutic target.