Applications of aryl-sulfinamides in the synthesis of N-heterocycles. Issue 33 (8th June 2021)

• Record Type: Journal Article
• Authors: Philip, Rose Mary; Treesa, G. S. Susan; Saranya, Salim; Anilkumar, Gopinathan
• Is Part Of: RSC advances. Volume 11:Issue 33(2021)
• Page Start: 20591
• Page End: 20600
• Publication Date: 2021-06-08
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d1ra04099e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The review comprehends the usage of arylsulfinamides for the construction of diverse N-heterocycles like piperidines, pyrrolidines, aziridines, and their fused derivatives. Abstract : Enantiopure aryl-sulfinamides are important chiral auxiliaries in the asymmetric synthesis of amines and their derivatives. Here, we provide an overview of arylsulfinamide mediated asymmetric methods towards N-heterocycle synthesis. This methodology through sulfinylimines offers general access to structurally diverse piperidines, pyrrolidines, aziridines and their derivatives which represent the structural motif of many natural products and therapeutically important compounds. The review covers articles from 2006–2020 and we have categorized the review based on the ring size as 3-, 5-, and 6- membered heterocycles and their derivatives.