Urinary metabolic characterization with nephrotoxicity for residents under cadmium exposure. (September 2021)

• Record Type: Journal Article
• Authors: Zeng, Ting; Liang, Yanshan; Chen, Jinyao; Cao, Guodong; Yang, Zhu; Zhao, Xingchen; Tian, Jinglin; Xin, Xiong; Lei, Bo; Cai, Zongwei
• Is Part Of: Environment international. Volume 154(2021)
• Publication Date: 2021-09
• Subjects: Cadmium -- Nephrotoxicity -- Metabolomics -- Human urine; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2021.106646
• Languages: English
• ISSNs: 0160-4120

Abstract

Graphical abstract: Highlights: Urines from female and male residents under cadmium exposure were investigated by mass spectrometry-based metabolomics. Biomarkers and metabolic pathways related to cadmium-induced nephrotoxicity were characterized. This study might provide information to reflect the body burden and help improve health policy for risk assessment. Abstract: Cadmium is a well-known hazardous pollutant that mainly comes from dietary, tobacco and occupational exposure, posing threat to kidney. However, there is still a lack of systematic study on metabolic pathways and urinary biomarkers related to its nephrotoxicity under cadmium exposure for both females and males. In this study, a mass spectrometry-based metabolomics investigation of a cohort of 144 volunteers was conducted to explore sex-specific metabolic alteration and to screen biomarkers related to cadmium-induced nephrotoxicity. When the concentration of urinary cadmium increased, creatine pathway, amino acid metabolism especially the tryptophan metabolism, aminoacyl-tRNA biosynthesis, and purine metabolism were primarily influenced regardless of the gender. Also, the most specific biomarkers linked with nephrotoxicity based on the statistical analysis were detected including creatine, creatinine, l -tryptophan, adenine and uric acid. The study outcome might provide information to reflect the body burden and help improve health policy for risk assessment.