Effectiveness of ketoacidosis prevention campaigns at diagnosis of type 1 diabetes in children: A systematic review and meta-analysis. (May 2021)

• Record Type: Journal Article
• Authors: Cherubini, Valentino; Marino, Monica; Carle, Flavia; Zagaroli, Luca; Bowers, Renee; Gesuita, Rosaria
• Is Part Of: Diabetes research and clinical practice. Volume 175(2021)
• Publication Date: 2021-05
• Subjects: Diabetic ketoacidosis -- Type 1 diabetes -- Diabetes Awareness Campaigns -- Diabetes symptoms -- Children and adolescents; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2021.108838
• Languages: English
• ISSNs: 0168-8227

Abstract

Highlights: Awareness campaigns are effective to reduce DKA at diagnosis of type 1 diabetes. Effectiveness depends on target population, geographical area, duration, tools used. Elements that make an awareness campaign effective are described. Abstract: Aim: To determine if diabetes awareness campaigns are an effective intervention to reduce diabetes ketoacidosis at diagnosis of type 1 diabetes in children and youth. Methods: Search strategies included PubMed, Scopus, CINAHL and WOS electronic databases, hand search of select journals and a grey literature search "Google" search to include all relevant information. Studies included community-based interventions focused on children younger than 18 years old. The difference in the frequency of DKA was measured in two separate comparisons; before and after perform awareness campaigns in the same area, and between areas with and without intervention campaigns. Results: Of 1136 records identified, 14 studies were eligible for the analysis. The first group of 12 studies measured DKA at diagnosis, before (n = 6548 individuals) and after (n = 4931 individuals) the awareness campaigns. The pooled difference was a reduction of 7.20% (95%CI: 0.99–13.41). The second group of four studies measured the difference in an area with no intervention (n = 338 individuals) and in an area with an awareness campaign (n = 187 individuals). The pooled difference in DKA was 35.71% (95%CI: 5.81–65.61). Conclusions: This review demonstrated that DKA awareness campaigns are effective to reduce DKA among children and adolescents with type 1 diabetes and the core components that explain why these campaigns are effective. Back to top.