Circadian clock effects on cellular proliferation: Insights from theory and experiments. (December 2020)

• Record Type: Journal Article
• Authors: Chakrabarti, Shaon; Michor, Franziska
• Is Part Of: Current opinion in cell biology. Volume 67(2020)
• Page Start: 17
• Page End: 26
• Publication Date: 2020-12
• Subjects: Circadian clock -- Mathematical modeling -- Computational biology; Cells -- Periodicals; Cytology -- Periodicals; Cell Biology -- Periodicals; Biology -- Periodicals; Cells -- Periodicals; Review Literature -- Periodicals; Cell Biology; Biology; Cells; Review Literature; Cellules -- Périodiques; Cytologie -- Périodiques; Electronic journals; 571.6
• DOI: 10.1016/j.ceb.2020.07.003
• Languages: English
• ISSNs: 0955-0674

Abstract

Abstract: Oscillations of the cellular circadian clock have emerged as an important regulator of many physiological processes, both in health and in disease. One such process, cellular proliferation, is being increasingly recognized to be affected by the circadian clock. Here, we review how a combination of experimental and theoretical work has furthered our understanding of the way circadian clocks couple to the cell cycle and play a role in tissue homeostasis and cancer. Finally, we discuss recently introduced methods for modeling coupling of clocks based on techniques from survival analysis and machine learning and highlight their potential importance for future studies.